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. Author manuscript; available in PMC: 2014 Mar 14.
Published in final edited form as: Neurosci Lett. 2013 Jan 24;537:71–76. doi: 10.1016/j.neulet.2013.01.017

Figure 1.

Figure 1

An acute, priming injection of cocaine elicits robust reinstatement of drug-seeking behavior in rats with cocaine self-administration experience. Total drug-paired lever responding for the 30-minute reinstatement test session is plotted for animals that received saline or cocaine challenge injection. There was a significant increase of drug-paired lever responding for cocaine-experienced rats that received cocaine compared to animals that received a saline injection. N = 7/group, “SA” = self-administration (The asterisk represents a significant difference from yoked-saline controls. 2-way ANOVA: Bonferroni p<0.001)