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. Author manuscript; available in PMC: 2014 Mar 14.
Published in final edited form as: Neurosci Lett. 2013 Jan 24;537:71–76. doi: 10.1016/j.neulet.2013.01.017

Figure 2.

Figure 2

Acute cocaine exposure increases expression of pGluA1-ser831 and pCaMKII-thr286 in the DL striatum and these effects are reversed after cocaine self-administration. Following an acute cocaine injection, yoked-saline controls show a significant increase in pGluA1-ser831 (A) and pCaMKII-thr286 (B) protein expression in the DL striatum. No significant changes in pGluA1-ser831 (A) and pCaMKII-thr286 (B) protein expression were observed in cocaine-experienced animals when compared to yoked-saline controls that received saline injections. There was no significant effect of training or challenge injection on native GluA1 (C) or native CaMKII (D) protein expression for any treatment. N = 4–7/group, “SA” = self-adminstration (Asterisks represent significant differences from yoked-saline controls that received a saline challenge injection. 2-way ANOVA: pGluA1 Bonferroni p<0.001; pCaMKII Bonferroni p<0.01)