An acute, priming cocaine injection decreases pGluA1-ser831 in the DM striatum regardless of cocaine experience. (A) pGluA1-ser831 protein expression was decreased in both cocaine-experienced rats and yoked-saline controls in the DM striatum after a cocaine challenge injection. There is no change in native GluA1 (B), pCaMKII-286 (C), or native CaMKII (D) protein expression in the DM striatum, regardless of cocaine experience. N = 4–7/group, “SA” = self-administration (The # represents a significant effect of challenge injection, p<0.05. There was no significant effect of pretreatment and no significant interaction.)