Skip to main content
. Author manuscript; available in PMC: 2014 Jun 1.
Published in final edited form as: Mol Neurobiol. 2012 Nov 20;47(3):857–867. doi: 10.1007/s12035-012-8377-3

Figure 3.

Figure 3

Effect of late and short term treatment of E2 and genistein on brain plaque formation. At an age of 9 months old, female mice were treated with 17β-estradiol (18.8ug/day), Genistein (26ug/day) or placebo for 3 months. At an age of 12 months, brain tissues were harvested. (A) Immunostaining of Aβ plaques as shown in dark brown in the images. (B) Plaque count was performed by Image-pro Plus Analysis (media Cybernetics) with three sizes as large (>20 µm diameter), medium (10–20 µm diameter) and small (>10 µm diameter). * P<0.05 compared to placebo group.