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Effect of estrogen treatment on insulin degradation enzyme (IDE) protein expression and enzyme activities in APP/OVX and APP/Ar+/− mice. All mice received 17β-estradiol (E), genistein (G) or placebo (C) as described in the methods. (A) The IDE western blot image is shown, (B) the corresponding densitometry analysis of the western blot image is shown, and (C) IDE enzyme activities are shown. No significant differences were found among all treatments and genotypes.
