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. Author manuscript; available in PMC: 2014 Feb 25.
Published in final edited form as: Dev Cell. 2013 Feb 25;24(4):345–358. doi: 10.1016/j.devcel.2013.01.012

Figure 5. Loss of Hdac1/2 expression does not disrupt postnatal airway epithelial homeostasis.

Figure 5

Hdac1 (A and B) and Hdac2 (C and D) expression are significantly reduced in the airway epithelium of Hdac1/2Scgb1a1creDKO mutants compared to Scgb1a1cre controls. Loss of Hdac1/2 expression in Hdac1/2Scgb1a1creDKO mutants does not disrupt airway epithelial morphology by H+E staining (E and I). Loss of Hdac1/2 expression in Hdac1/2Scgb1a1creDKO mutants does not disrupt expression of secretory cell markers Scgb1a1 (F and J) and Sox2 (G and K). Loss of Hdac1/2 expression does not disrupt expression of the ciliated epithelial marker TubbIV (H and L). Q-PCR shows only a minor loss of expression for the secretory marker genes Scgb1a1 and Scgb3a2 and no significant change in Sox2 expression in Hdac1/2Scgb1a1creDKO mutants. Q-PCR data shown are the average of 3-5 assays ± S.E.M. Scale bars=20μm.