Table I.
Irradiation condition | miRNA ID | Only expressed in one condition?a |
Fold change ± SEM |
p-value | FDR |
---|---|---|---|---|---|
γ 6 h 0.5 Gy | miR-511 | R | 197.0 ± 1.18 | 5.2E-08 | 9.4E-06 |
miR-598 | R | 20.0 ± 2.89 | 1.6E-06 | 1.4E-04 | |
γ 6 h 1.5 Gy | miR-135a | 4.0 ± 1.26 | 6.3E-04 | 0.0182 | |
miR-147 | R | 80.6 ± 3.30 | 3.1E-07 | 2.7E-05 | |
miR-150 | −2.2 ± 1.17 | 0.0028 | 0.0676 | ||
miR-200b | C | −686.4 ± 28.72 | 2.1E-07 | 2.7E-05 | |
miR-547 | C | −18.8 ± 4.14 | 9.9E-06 | 5.6E-04 | |
miR-680 | R | 182.8 ± 1.59 | 1.3E-05 | 5.6E-04 | |
miR-685 | R | 170.0 ± 12.34 | 3.6E-05 | 0.0029 | |
miR-708 | C | −43.0 ± 5.35 | 2.2E-04 | 0.0075 | |
γ 6 h 5.0 Gy | miR-10a | 1.8 ± 1.08 | 0.0027 | 0.0529 | |
miR-135a | 19.9 ± 1.15 | 8.0E-07 | 4.6E-05 | ||
miR-135b | 8.1 ± 1.54 | 0.0010 | 0.0267 | ||
miR-139-5p | 3.8 ± 1.23 | 4.0E-04 | 0.0140 | ||
miR-147 | R | 215.0 ± 3.24 | 0.0011 | 0.0267 | |
miR-223 | 3.6 ± 1.09 | 4.1E-05 | 0.0018 | ||
miR-450a-5p | 2.2 ± 1.12 | 0.0012 | 0.0267 | ||
miR-680 | R | 2530.0 ± 1.35 | 4.9E-08 | 4.3E-06 | |
miR-685 | R | 2430.0 ± 12.55 | 5.9E-09 | 1.0E-06 | |
γ 24 h 1.5 Gyb | miR-335-3p | 4.2 ± 1.25 | 2.6E-04 | 0.0229 | |
miR-667 | C | −91.8 ± 6.05 | 4.5E-09 | 8.0E-07 | |
γ 24 h 5.0 Gy | miR-125a-3p | 3.6 ± 1.35 | 0.0020 | 0.0327 | |
miR-146a | −3.9 ± 1.33 | 0.0011 | 0.0221 | ||
miR-150 | −19.7 ± 1.39 | 1.5E-05 | 5.3E-04 | ||
miR-151-3p | 2.5 ± 1.21 | 0.0031 | 0.0453 | ||
miR-211 | C | −377.2 ± 5.97 | 3.0E-07 | 1.3E-05 | |
miR-335-3p | 3.7 ± 1.27 | 7.5E-04 | 0.0166 | ||
miR-337-3p | C | −30.0 ± 3.67 | 1.4E-04 | 0.0042 | |
miR-339-3p | 3.1 ± 1.24 | 0.0013 | 0.0235 | ||
miR-342-3p | −6.5 ± 1.39 | 3.3E-04 | 0.0083 | ||
miR-501-3p | R | 12300.0 ± 1.18 | 3.3E-10 | 5.9E-08 | |
miR-511 | R | 107.0 ± 6.45 | 1.1E-07 | 9.6E-06 | |
miR-667 | C | −100.1 ± 4.22 | 2.4E-07 | 1.3E-05 | |
56Fe 6 h 0.1 Gy | miR-125a-3p | C | −117.1 ± 3.75 | 1.5E-08 | 2.7E-06 |
miR-350 | −1.7 ± 1.06 | 3.7E-04 | 0.0169 | ||
miR-379 | R | 680.3 ± 1.61 | 8.1E-06 | 5.0E-04 | |
miR-383 | C | −21.5 ± 1.24 | 6.9E-06 | 5.0E-04 | |
56Fe 6 h 0.5 Gy | miR-383 | C | −20.2 ± 1.25 | 4.4E-06 | 2.7E-04 |
miR-501-3p | R | 336.9 ± 16.75 | 1.7E-10 | 3.1E-08 | |
miR-680 | R | 107.6 ± 7.62 | 5.2E-07 | 4.7E-05 | |
56Fe 24 h 0.1 Gy | miR-409-3p | R | 64.1 ± 6.47 | 1.0E-08 | 9.8E-07 |
miR-685 | R | 292.8 ± 10.76 | 7.0E-10 | 1.3E-07 | |
56Fe 24 h 0.5 Gy | miR-150 | −2.5 ± 1.17 | 8.6E-04 | 0.0326 | |
miR-211 | −2.2 ± 1.10 | 2.5E-04 | 0.0232 | ||
miR-342-3p | −2.2 ± 1.12 | 4.4E-04 | 0.0278 | ||
miR-494 | −2.4 ± 1.17 | 8.1E-04 | 0.0326 | ||
miR-879 | R | 35.3 ± 6.15 | 1.8E-08 | 3.4E-06 |
ID, identification; SEM, standard error of the mean; FDR, false discovery rate.
MicroRNA that are only expressed in the sham-irradiated controls (C) or after exposure to ionising radiation (R).
No miRNA were differentially expressed after 0.5 Gy γ irradiation at the 24 h time point.