. Author manuscript; available in PMC: 2013 Nov 1.

Published in final edited form as: Am J Obstet Gynecol. 2012 Aug 16;207(5):398.e1–398.e8. doi: 10.1016/j.ajog.2012.08.015

TABLE 3.

Relationship between BMI and 17-OHPC exposures for pharmacokinetic studies 1 and 2

Pharmacokinetic study		BMI r	P value
BMI vs AUC^t1_t2

	PK1	0.36	< .01

	PK2	0.50	< .01

BMI vs C_trough

	PK1	0.29	< .01

	PK2	0.41	< .01

Correlation coefficient (r) between BMI (independent variable) and area under the concentration (AUC) or the minimum concentration at time zero just before the next injection (C_trough; dependent variables). The AUC vs time curve (AUC^t1_t2) was measured in nanograms per milliliter per day; C_trough was measured in nanograms per milliliter.

BMI, body mass index; 17-OHPC, 17-hydroxyprogesterone caproate.

Caritis. Pharmacology and placental transport of 17-OHPC. Am J Obstet Gynecol 2012.