Table 2.
Hyporesponsiveness categories for total erythropoietin dose
| |
|
Hyporesponsiveness |
Squared difference |
||||
|---|---|---|---|---|---|---|---|
| All | None | Chronic | Acute | Other | Other - chronic | Other - acute | |
|
n |
138,688 |
111,422 |
6248 |
7219 |
13,799 |
|
|
|
Sex |
|||||||
| Men |
51.8 |
51.6 |
54.7 |
51.0 |
52.5 |
4.9 |
2.3 |
| Women |
48.2 |
48.4 |
45.3 |
49.0 |
47.5 |
|
|
|
Race |
|||||||
| White |
51.4 |
52.6 |
46.2 |
47.4 |
46.0 |
0.1 |
1.8 |
| African American |
42.2 |
40.5 |
49.8 |
47.5 |
49.5 |
0.1 |
4.1 |
| Other |
6.4 |
6.9 |
3.9 |
5.1 |
4.4 |
|
|
|
Age, years |
|||||||
| < 40 |
8.1 |
7.5 |
12.9 |
9.8 |
10.3 |
7.0 |
0.2 |
| 40-64 |
44.3 |
42.7 |
54.9 |
48.3 |
50.3 |
20.6 |
4.1 |
| 65-74 |
24.9 |
25.5 |
19.8 |
24.5 |
22.8 |
9.3 |
2.9 |
| ≥ 75 |
22.7 |
24.4 |
12.5 |
17.4 |
16.6 |
|
|
|
Cause of renal failure |
|||||||
| Diabetes |
44.9 |
45.3 |
38.7 |
45.7 |
44.1 |
29.0 |
2.8 |
| Hypertension |
29.3 |
29.6 |
27.8 |
27.8 |
28.8 |
1.0 |
1.1 |
| Glomerulonephritis |
10.2 |
10.0 |
12.2 |
10.3 |
10.7 |
2.2 |
0.1 |
| Cystic kidney disease |
2.2 |
2.2 |
2.1 |
2.0 |
1.8 |
0.1 |
0.1 |
| Other |
13.5 |
13.0 |
19.3 |
14.2 |
14.7 |
|
|
|
Dialysis duration, years |
|||||||
| < 1 |
9.6 |
9.8 |
7.7 |
9.4 |
8.6 |
0.9 |
0.5 |
| 1 to < 3 |
32.6 |
33.5 |
26.3 |
31.3 |
28.9 |
6.7 |
5.8 |
| 3 to < 5 |
23.6 |
23.6 |
23.2 |
23.0 |
23.8 |
0.3 |
0.7 |
| ≥ 5 |
34.3 |
33.1 |
42.8 |
36.4 |
38.7 |
|
|
|
Average BMI, kg/m2 |
|||||||
| < 18.5 |
3.7 |
3.6 |
3.3 |
4.3 |
3.8 |
0.2 |
0.3 |
| ≥ 18.5 and < 25 |
34.9 |
35.2 |
30.4 |
36.5 |
33.5 |
9.4 |
8.8 |
| ≥ 25 and < 30 |
28.5 |
28.9 |
25.6 |
27.6 |
27.3 |
2.8 |
0.1 |
| ≥ 30 |
33.0 |
32.3 |
40.7 |
31.6 |
35.4 |
|
|
|
Antecedent comorbid conditions |
|||||||
| ASHD |
22.0 |
20.4 |
26.0 |
29.8 |
28.5 |
6.3 |
1.6 |
| CHF |
19.6 |
17.2 |
29.9 |
29.7 |
28.8 |
1.3 |
0.8 |
| CVA/TIA |
7.4 |
6.9 |
7.5 |
10.9 |
9.6 |
4.0 |
1.9 |
| PVD |
16.5 |
14.8 |
23.1 |
24.2 |
23.3 |
0.1 |
0.9 |
| Other cardiac disease |
12.4 |
10.6 |
20.3 |
20.0 |
19.2 |
1.1 |
0.6 |
| COPD |
8.4 |
7.3 |
13.2 |
12.7 |
12.9 |
0.1 |
0.0 |
| GI bleeding |
3.3 |
2.5 |
7.2 |
6.1 |
6.1 |
1.2 |
0.0 |
| Liver disease |
5.5 |
5.2 |
7.4 |
6.3 |
6.8 |
0.3 |
0.3 |
| Dysrhythmia |
13.7 |
12.4 |
19.1 |
19.2 |
18.8 |
0.0 |
0.1 |
| Cancer |
4.1 |
3.6 |
7.2 |
5.3 |
5.8 |
2.1 |
0.2 |
| Diabetes |
49.7 |
48.9 |
49.2 |
55.0 |
53.0 |
14.1 |
4.1 |
|
Concurrent comorbid conditions |
|||||||
| ASHD |
30.1 |
28.4 |
32.9 |
41.2 |
37.0 |
16.8 |
17.3 |
| CHF |
27.6 |
24.6 |
38.9 |
42.9 |
39.1 |
0.0 |
14.7 |
| CVA/TIA |
10.9 |
10.2 |
10.5 |
16.9 |
13.5 |
9.3 |
11.3 |
| PVD |
24.8 |
22.8 |
30.3 |
35.8 |
32.7 |
5.6 |
10.0 |
| Other cardiac disease |
19.7 |
17.2 |
28.3 |
32.4 |
28.8 |
0.3 |
12.5 |
| COPD |
12.5 |
11.1 |
18.2 |
19.2 |
17.9 |
0.1 |
1.6 |
| GI bleeding |
5.3 |
4.1 |
10.6 |
11.2 |
9.6 |
1.0 |
2.7 |
| Liver disease |
6.4 |
6.0 |
8.9 |
7.8 |
8.0 |
0.9 |
0.0 |
| Dysrhythmia |
19.8 |
18.1 |
25.1 |
28.4 |
26.4 |
1.8 |
3.9 |
| Cancer |
5.6 |
5.0 |
9.9 |
7.2 |
7.6 |
5.5 |
0.1 |
| Diabetes |
57.3 |
56.7 |
55.6 |
62.1 |
60.2 |
20.8 |
3.7 |
|
Number of vascular access complication |
|||||||
| 0 |
61.9 |
61.9 |
64.0 |
55.4 |
53.7 |
106.1 |
2.7 |
| 1-3 |
19.9 |
19.9 |
19.1 |
21.7 |
23.4 |
17.8 |
2.7 |
| ≥ 4 |
18.2 |
18.2 |
16.9 |
22.9 |
22.9 |
|
|
|
Average iron dose per month, mg |
|||||||
| Non-users |
15.1 |
16.2 |
13.0 |
9.5 |
10.4 |
7.1 |
0.7 |
| < 233 |
21.1 |
23.0 |
11.4 |
14.6 |
13.9 |
6.6 |
0.5 |
| ≥ 233 and < 360 |
21.1 |
21.5 |
16.6 |
20.2 |
20.1 |
12.0 |
0.0 |
| ≥ 360 and < 460 |
20.9 |
20.5 |
20.9 |
23.9 |
22.5 |
2.5 |
2.0 |
| ≥ 460 |
21.8 |
18.8 |
38.1 |
31.8 |
33.2 |
24.5 |
1.9 |
|
IV antibiotic use |
|||||||
| No |
76.9 |
76.9 |
79.6 |
65.6 |
66.6 |
168.0 |
1.0 |
| Yes |
23.1 |
23.1 |
20.5 |
34.4 |
33.4 |
|
|
|
Number of hospital admissions |
|||||||
| 0 |
63.3 |
63.3 |
68.3 |
45.7 |
44.8 |
549.0 |
0.8 |
| 1 |
20.8 |
20.8 |
19.4 |
26.7 |
26.0 |
43.2 |
0.5 |
| ≥ 2 |
15.9 |
15.9 |
12.3 |
27.6 |
29.2 |
|
|
|
Number of hospitalization days |
|||||||
| 0 |
63.3 |
63.3 |
68.3 |
45.7 |
44.8 |
549.0 |
0.8 |
| 1-7 |
18.4 |
18.4 |
17.3 |
24.4 |
22.4 |
25.6 |
4.2 |
| ≥ 8 |
18.4 |
18.4 |
14.4 |
29.8 |
32.8 |
|
|
|
Infectious hospitalizations |
|||||||
| No |
88.2 |
88.2 |
90.6 |
80.3 |
79.2 |
129.8 |
1.2 |
| Yes |
11.8 |
11.8 |
9.4 |
19.7 |
20.8 |
|
|
|
Dialysis provider |
|||||||
| Non-profit |
14.0 |
14.0 |
14.7 |
12.4 |
11.0 |
13.0 |
1.7 |
| For profit |
85.0 |
85.0 |
84.4 |
86.5 |
87.6 |
9.8 |
1.1 |
| Unknown |
1.0 |
1.0 |
0.9 |
1.1 |
1.4 |
|
|
|
Region |
|||||||
| Northeast |
15.7 |
15.7 |
15.7 |
15.0 |
15.1 |
0.4 |
0.0 |
| Midwest |
19.1 |
19.1 |
19.4 |
19.0 |
17.8 |
2.6 |
1.5 |
| South |
45.2 |
45.2 |
43.7 |
50.8 |
51.9 |
67.9 |
1.2 |
| West |
17.2 |
17.2 |
18.3 |
12.6 |
12.6 |
33.1 |
0.0 |
| Unknown |
2.8 |
2.8 |
2.9 |
2.7 |
2.7 |
|
|
| Distance | -- | -- | -- | -- | -- | 43.6 | 12.0 |
ASHD, atherosclerotic heart disease; BMI, body mass index; CHF, congestive heart failure; COPD, chronic obstructive pulmonary disease; CVA/TIA, cerebrovascular accident/transient ischemic attack; GI, gastrointestinal; IV, intravenous; PVD, peripheral vascular disease.