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. 2013 Feb 25;13:88. doi: 10.1186/1471-2407-13-88

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Copyright ©2013 Jordaan et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Effect of HDAC inhibitors on the E-cadherin transcripts. A. RT-PCR analysis to determine the change in expression of wild type E-cadherin transcripts with HDACi MS-275 treatment. Two primary CLL specimens were treated with two different concentrations of HDACi MS-275 (0.1μM and 1.0μM for 48 hours). (Data from two experiments, mean and SD). B. Western blot analysis of two CLL specimens that were treated with HDACi MS-275 (1μM for 48 hours). Lysates analyzed for acetylated histones H3 (Ac-H3), acetylated histone H4 antibodies (Ac-H4) with antibodies that recognize the acetylated histones and actin control.