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. Author manuscript; available in PMC: 2014 Feb 20.
Published in final edited form as: Neuron. 2013 Feb 20;77(4):647–654. doi: 10.1016/j.neuron.2012.12.033

Figure 1. Effects of Disc1 Knockdown on Cognitive and Affective Behaviors.

Figure 1

(A) Representative images of adult-born DG neurons infected with shRNA-Cont or shRNA-DISC1 virus (blue: DAPI; green: GFP, imaged 3 weeks after virus injection). Scale bar: 20 μm. (B) Total number of GFP+ neurons in DG. (C) The percentage of exploration time during the object-place recognition test at 24 h after training (shRNA-Cont n=8, shRNA-DISC1 n=7; *P<0.05, one sample t-test compared to 50%). (D) The percent of exploration time during the novel object recognition test at 24 h after training (shRNA-Cont n=8, shRNA-DISC1 n=7; *P<0.05, **P<0.01, one sample t-test compared to 50%). (E) In the forced swim test, the immobility time of shRNA-DISC1 mice (n=7) was significantly higher than shRNA-Cont mice (n=8; *P<0.05, t-test). (F) In the elevated plus maze test, shRNA-DISC1 mice spent less percentage time in the open arms of the plus maze than shRNA-Cont mice (shRNA-Cont n=7, shRNA-DISC1 n=7; *P<0.05, t-test). All data are shown as means ± s.e.m.