Table 1.
Baseline characteristics, and baseline, follow-up and change in CAC, in 605 Epidemiology of Coronary Artery Calcification Study participants by MGP genotype; data are mean (standard deviation) or n (%); P-value is from comparison across genotype.
| Characteristic | Thr83Thr (n=190) | Thr83Ala (n=322) | Ala83Ala (n=93) | P |
|---|---|---|---|---|
| Age (years) | 51.8 (9.5) | 51.5 (10.2) | 51.6 (12.3) | 0.885 |
| Male | 92 (48.4%) | 167 (51.9%) | 50 (53.8%) | 0.357 |
| Systolic BP (mm Hg) | 118.9 (14.8) | 118.1 (16.6) | 119.1 (15.7) | 0.941 |
| Diastolic BP (mm Hg) | 77.0 (9.4) | 76.4 (9.5) | 77.8 (9.5) | 0.716 |
| Cholesterol (mg/dL) | 192.8 (41.2) | 195.7 (36.6) | 189.8 (36.8) | 0.762 |
| High-density lipoprotein cholesterol (mg/dL) | 44.9 (12.7) | 45.5 (13.0) | 45.6 (15.5) | 0.594 |
| Fasting glucose (mg/dL) | 88.3 (10.7) | 88.7 (10.2) | 89.3 (17.6) | 0.518 |
| Current smoker | 14 (7.4%) | 36 (11.2%) | 18 (19.4%) | 0.004 |
| Hypertension | 40 (21.1%) | 54 (16.8%) | 20 (21.5%) | 0.787 |
| Anti-hypertensive Medication | 16 (8.4%) | 32 (9.9%) | 17 (18.3%) | 0.025 |
| Body Mass Index (kg/m2) | 27.2 (4.8) | 27.0 (4.5) | 26.7 (4.6) | 0.319 |
| Waist Circumference (cm) | 86.8 (12.7) | 86.2 (13.1) | 86.1 (12.0) | 0.631 |
| Abdominal Obesity | 35 (18.4%) | 58 (18.0%) | 13 (14.0%) | 0.421 |
| Detectable CAC at baseline | 81 (42.6%) | 142 (44.1%) | 42 (45.2%) | 0.828‡ |
| Detectable CAC at follow-up* | 71 (56.4%) | 144 (64.0%) | 39 (69.6%) | 0.046‡ |
| Baseline CAC area (mm2) | 25.8 (76.3) | 22.3 (70.8) | 20.4 (49.2) | 0.833‡ |
| Follow-up CAC area (mm2)* | 36.2 (98.1) | 51.8 (137.4) | 53.6 (101.5) | 0.070‡ |
| Average change in CAC area (mm2/year)*,† | 2.4 (6.4) | 3.8 (9.8) | 3.8 (6.9) | 0.065‡ |
| Time between baseline and follow-up examinations (years)* | 10.5 (1.5) | 10.2 (1.4) | 10.4 (1.5) | 0.328‡ |
CAC, coronary artery calcification; MGP, matrix Gla protein; Thr, threonine; Ala, alanine; BP, blood pressure
407 participants had follow-up examinations (56 participants with Ala83Ala genotype, 225 participants with Thr83Ala genotype, and 126 participants with Thr83Thr genotype)
Defined as (follow-up - baseline CAC area)/time between examinations (in years)
Adjusted for male sex and age at examination; average change in CAC area additionally adjusted for baseline CAC quantity; CAC quantity variables log-transformed.