. Author manuscript; available in PMC: 2014 Mar 1.

Published in final edited form as: Arterioscler Thromb Vasc Biol. 2013 Jan 10;33(3):645–651. doi: 10.1161/ATVBAHA.112.300491

Table 4.

Progression of coronary artery calcification (CAC) quantity was modified by MGP proxy SNP rs6488724 genotype (additive model for increase in A allele). Linear mixed effects model results for log(CAC quantity+1) among 246 GENOA-Rochester participants (replication sample).

Covariate	Model I^*		Model II^†
Covariate	β±se	P	β±se	P
Time (years)	−0.19±0.01	0.006	−0.36±0.08	<0.001
rs6488724	−0.10±0.15	0.486	−0.10±0.15	0.492
Time^* rs6488724	0.03±0.01	0.011	0.03±0.01	0.009

SNP, single nucleotide polymorphism; β, parameter estimate; se, standard error

Adjusted for sex, baseline age, time between exams, a time-by-age interaction term and a time-by-sex interaction term.

^†

Additionally adjusted for systolic blood pressure (SBP), a time-by-SBP interaction term, smoking status, a time-by-smoking status interaction term, total cholesterol, high-density lipoprotein cholesterol, antihypertensive medication use and abdominal obesity.