Table 1.
Distribution of reported adverse events and type of vaccine; Rondônia 1999–2008.
| Event type | Vaccines | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| DTP | DTP/Hib | HB | MMR | YF | BCG | |||||||
| N | % | N | % | N | % | N | % | N | % | N | % | |
| Systemic | ||||||||||||
| Headache and vomiting | 3 | 2.61 | 6 | 2.01 | 0 | 0.00 | 1 | 3.57 | 0 | 0 | 0 | 0.00 |
| Afebrile seizure | 2 | 1.74 | 9 | 3.02 | 1 | 3.23 | 0 | 0.00 | 0 | 0 | 0 | 0.00 |
| Febrile seizure | 19 | 16.52 | 37 | 12.42 | 1 | 3.23 | 0 | 0.00 | 0 | 0 | 0 | 0.00 |
| Induration | 2 | 1.74 | 4 | 1.34 | 3 | 9.68 | 0 | 0.00 | 1 | 5 | 0 | 0.00 |
| Hypotonic hyporesponsive episodes | 35 | 30.43 | 124 | 41.61 | 1 | 3.23 | 1 | 3.57 | 0 | 0 | 0 | 0.00 |
| Generalized rash | 2 | 1.74 | 12 | 4.03 | 3 | 9.68 | 8 | 28.57 | 4 | 20 | 0 | 0.00 |
| Fever ≥39.5°C | 30 | 26.09 | 52 | 17.45 | 1 | 3.23 | 2 | 7.14 | 0 | 0 | 1 | 4.17 |
| Fever ≤39.5°C | 1 | 0.87 | 16 | 5.37 | 1 | 3.23 | 3 | 10.71 | 1 | 5 | 1 | 4.17 |
| Other serious events and/or unusual | 2 | 1.74 | 8 | 2.68 | 3 | 9.68 | 1 | 3.57 | 0 | 0 | 0 | 0.00 |
| Hypersensitivity reaction to 2 h | 2 | 1.74 | 3 | 1.01 | 1 | 3.23 | 5 | 17.86 | 5 | 25 | 0 | 0.00 |
| Hypersensitivity reaction after 2 h | 4 | 3.48 | 6 | 2.01 | 0 | 0.00 | 2 | 7.14 | 5 | 25 | 0 | 0.00 |
| Others | 1 | 0.88 | 2 | 0.67 | 0 | 0.00 | 2 | 7.1 | 2 | 10 | 0 | 0.00 |
| Local | ||||||||||||
| Pain/redness/heat | 4 | 3.48 | 7 | 2.35 | 0 | 0.00 | 0 | 0.00 | 1 | 5 | 0 | 0.00 |
| Local hot abscess | 4 | 3.48 | 2 | 0.67 | 13 | 41.94 | 1 | 3.57 | 0 | 0 | 0 | 0.00 |
| Others | 4 | 3.48 | 10 | 3.36 | 3 | 9.7 | 2 | 7.1 | 1 | 5 | 22 | 91.67 |
|
| ||||||||||||
| Total | 115 | 100% | 298 | 100% | 31 | 100% | 28 | 100% | 20 | 100% | 24 | 100% |
Percentage (%) was calculated from the number of specific cases and total number of reported cases.
Source: “ SI-EAPV do Programa de Imunizações do Estado de Rondônia” (EAPV Registry of Rondonia). BCG: Bacillus Calmette-Guérin; HB: hepatitis B; DTP+Hib: diphtheria-tetanus-pertussis+Hemophillus influenza b; DTP: diphtheria-tetanus-pertussis; MMR: mumps, measles, rubella; YF: yellow fever.