TABLE 1.
Genes Containing Iron Response Elements
Gene symbol | UTR | Protein name | Proposed function |
---|---|---|---|
ALAS25 | 5′ | 5′ aminolevulinic acid synthase | Heme synthesis |
APP41 | 5′ | Amyloid precursor protein | Alzheimer’s disease pathogenesis |
CDC14A18 | 3′ | Cell division cycle homolog A | Phosphatase; cell cycle |
DMT15 | 3′ | Divalent metal transporter 1 | Iron import |
EPAS127 | 5′ | HIF-2α | Hypoxia-induced transcription |
FTH5 | 5′ | Ferritin heavy chain | Iron storage |
FTL5 | 5′ | Ferritin light chain | Iron storage |
mACO18 | 5′ | Mitochondrial aconitase | Citrate-isocitrate conversion |
SLC40A15 | 5′ | Ferroportin | Iron export |
SNCA42 | 5′ | Alpha-synuclein | Synucleinopathy pathogenesis |
TFRC5 | 3′ | Transferrin receptor 1 | Cellular iron uptake |