Fig 6.
A model of the effects of MK-STYX or MK-STYXactive on G3BP-1-induced stress granules. (A) Overexpression of G3BP-1 induces stress granules, which are inhibited by MK-STYX. (B) MK-STYX inhibits stress granule formation by the G3BP-1 nonphosphorylatable mutant S149A-G3BP-1. (C) The phosphomimetic mutant S149E-G3BP-1 does not aggregate to form stress granules. (D) Heat shock induces S149E-G3BP-1 stress granules, although their formation is blocked by MK-STYX. (E) MK-STYXactive induces stress granules.