Figure 5. Transport of exenatide across Caco-2 monolayers.

Apical-to-basolateral permeability of exenatide was measured at different apical loading. TEER values were determined to ensure monolayer integrity. (a) TEER values of Caco-2 monolayer following apical loading of different concentrations of exenatide at 0.3 (circles), 1.0 (triangles), 3.0 (diamonds), and 9.0 (crosses) µg/well. (b) Cumulative transport of exenatide (µg) to basolateral chamber during the experiment at different apical loading concentrations of 0.3 (filled circles), 1.0 (open circles), 3.0 (squares), and 9.0 (triangles) µg/well. Data represent mean±SD (n = 3).