Figure 2. Positions of methionines in active and inactive β2AR structures.
A) Methionine residues shown as sticks in the active and inactive β2AR crystal structures. Solid spheres represent the methionine methyl carbons left in β2AR-Δ5, whereas dotted spheres represent methyls of methionines mutated to other residues in β2AR-Δ5. The functional properties of β2AR-Δ5 are similar to those of wild-type β2AR (See also Fig. S1). B) Structure of β2AR in the crystallographic inactive conformation (2RH1) seen from the intracellular side. Leu2726.34 and surrounding hydrophobic residues are shown as sticks. C) Structure of β2AR in the crystallographic active conformation (3P0G) seen from the intracellular side.