Table 5.
Genomic Segments of Total CNVs That Were Independent Predictors of OS
| ID | Chr | Band | Start-end | No. of SNPs | No. of Pat sharing MR | Start MR | P value for CLL vs HapMap | P value for TTT univ | HR TTT univ | P value for TTT multiv | HR TTT multiv | P value for OS univ | Log HR OS univ | P value for OS multiv | Log HR OS multiv | Potential key gene in MR or overall segment | Structural variation in DGV (MR) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| LT0001 | 1 | p36.21 | 12767427-13614996 | 102 | 10 | 12821696-12836483 | 0.3031 | 0.6416 | 1.20 | 0.5141 | 1.30 | 0.0309 | −17.09 | 0.0914 | −16.94 | HNRNPCL1 | Yes |
| GT0137 | 5 | q13.2 | 68862825-69475807 | 105 | 11 | 69328189-69379245 | 0.5663 | 0.0607 | 1.91 | 0.0366 | 2.09 | 0.0305 | 1.09 | 0.0504 | 0.99 | SMA4 and SERF1A/B | Yes |
| GT0159 | 6 | p21.32 | 32518405-32619844 | 113 | 12 | 32616865-32616865 | 0.9754 | 0.0339 | 2.19 | 0.3749 | 1.38 | 0.0738 | 0.97 | 0.0597 | 1.09 | HLA,DRA, DRB1, and DRB5 | Yes |
| LT0267 | 8 | p22 | 13620726-13654984 | 26 | 5 | 13620726-13654984 | 0.0723 | 0.7886 | 1.15 | 0.8109 | 1.13 | 0.0916 | 1.19 | 0.0336 | 1.59 | None | Yes |
| LT0294 | 8 | q24.3 | 141086472-141321409 | 152 | 10 | 141189636-141189852 | 0.0699 | 0.4621 | 1.32 | 0.2940 | 1.51 | 0.0695 | 1.12 | 0.0428 | 1.28 | TRAPPC9 | Yes |
| LT0354 | 11 | p15.4 | 3383178-3888105 | 110 | 5 | 3588683-3686252 | 0.0723 | 0.1159 | 2.52 | 0.2153 | 2.05 | 0.0117 | 1.96 | 0.0211 | 1.78 | ART1/5 and NUP98 | Yes |
| GT0311 | 13 | q13.2--q13.3 | 33937199-35109143 | 303 | 5 | 34542952-34877387 | 0.0723 | 0.6773 | 1.22 | 0.5043 | 1.38 | 0.0950 | 1.18 | 0.1028 | 1.16 | NBEA | Yes |
| GT0380 | 20 | p11.1 | 25710186-25971373 | 64 | 5 | 25894996-25897274 | 0.4773 | 0.3422 | 1.59 | 0.6163 | 1.27 | 0.0050 | 1.87 | 0.0273 | 1.44 | None | Yes |
| LT0551 | 22 | q11.23 | 22448589-23491733 | 260 | 25 | 22688572-22715105 | 0.1200 | 0.9409 | 0.98 | 0.4202 | 0.82 | 0.0226 | 0.88 | 0.0936 | 0.67 | GSTT1 | Yes |
P < 0.05 values are boldfaced.
Chr, chromosome; DGV, Database of Genomic Variants (http://projects.tcag.ca/variation, last accessed January 1, 2012); multiv, in multivariate analysis; Pat, patients; univ, in univariate analysis.