Figure 6.

Glucose, glucagon, hepatic gluconeogenesis in control and infected mice 30 days postinfection. A: Infected mice had an average blood sugar of 70 mg/dL compared with 150 mg/dL for control (P < 0.05) (n = 5 each group). B: In response to the hypoglycemia and hypoinsulinemia, there were increased glucagon levels in the sera of infected mice (P < 0.05) (n = 3 each group). C: Pyruvate tolerance test: infected and uninfected mice 30 days postinfection were injected i.p. with 2 g/kg sodium pyruvate. Blood glucose was determined at 0, 5, 15, 30, 60, 90, and 120 minutes after injection. There was a significant reduction in glucose at every time point (P < 0.05) (n = 5 each group). D: Pyruvate tolerance test: reduction of mRNA expression of glucose-6-phosphatase in livers of infected mice compared with livers obtained from control mice. (P < 0.05) (n = 3 each group). All determinations were made on mice that were fasted for at least 7 hours.