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NR2B subunit antagonist attenuates hypotonicity-increased INMDA. (A) In the presence of ifenprodil, the current was almost not changed by hypotonic stimulation and the increase in INMDA by hypotonicity was markedly attenuated from 39.0 ± 5.4% (n = 17) to 3.8 ± 1.8% (n = 18). **P < 0.01 vs. 240 mOsm/kg (B) Pre-application of NVP-AAM007, INMDA was increased 37.8 ± 4.2% (n = 14) by hypotonic stimulation, which was not different from the increase by hypotonicity alone.
