Table 2. Manual intra- and inter-physician segmentation results (min, max, mean μ and standard deviation σ) for three neurosurgeons – X, Y and Z – for twelve glioblastoma multiforme (GBM) data sets. The first column represents the intra-physician segmentation result: within a time distance of two weeks Physician X segmented the twelve GBMs slice-by-slice twice. The second and third columns present the inter-physician segmentation results, whereby the manual slice-by-slice segmentations form Physician Y and Physician Z have been compared with the first manual segmentation of Physician X.

	DSC for intra- and inter-physician segmentations
	Physician X	Physician Y	Physician Z
Min	84.01%	78.68%	76.03%
Max	96.30%	94.86%	94.83%
μ ± σ	90.29 ± 4.48%	88 ± 6.08%	86.63 ± 6.87%