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. Author manuscript; available in PMC: 2014 Apr 1.
Published in final edited form as: Oral Oncol. 2012 Nov 19;49(4):287–292. doi: 10.1016/j.oraloncology.2012.10.009

Figure 4. TGFβ and EGF in EMT.

Figure 4

(A) TGFβ post-transcriptionally regulates MMP9 through SMAD2/3 and MLCK to promote EMT. Transcriptional regulation of MMP9 by TGFβ is mediated through the Snail/Ets1 and MEK1/2-ERK1/2-Slug pathways. (B) EGF activates Erk1/2 and AKT pathways to promote EMT. EGF activates the EGFR to increase MMP9 resulting in degradation of E-Cadherin into sE-Cadherin. Also, the EGF/EGFR signaling pathway regulates the degradation of desmosomes.