Table 1.

[³H]Ketanserin binding displacement curves by DOI in frontal cortex membrane preparations of antipsychotic-free (AP-F) schizophrenics, antipsychotic-treated (AP-T) schizophrenics, and controls.

	Control	Schizophrenia(AP-F)	Control	Schizophrenia (AP-T)
log Ki-high	−10.21 ± 0.32	−10.20 ± 0.15***	−10.78 ± 0.33	−10.53 ± 0.33*,+
Fraction high (%)	5.51 ± 1.06	10.34 ± 0.88***	−05.75 ± 1.01	8.76 ± 1.51*,+
log Ki-medium	−7.70 ± 0.05	−7.55 ± 0.03***	0-7.69 ± 0.04	−7.56 ± 0.07*,+
Fraction medium (%)	72.5 ± 5.31	73.8 ± 1.68***	--78.0 ± 2.74	75.2 ± 4.20*,+
log Ki-low	−6.25 ± 0.16	−5.91 ± 0.19***	0-6.06 ± 0.23	−5.94 ± 0.37*,+

^*p<0.05;

^***p<0.001 when compared with individually matched control subjects by Student’s t-test.

⁺p<0.05 when compared with antipsychotic-free schizophrenic subjects by Student’s t-test.

Data were best fit to a triphasic compared to biphasic displacement curve by F-test (p<0.0001).

See Supplementary Tables 1 and 2 for demographic information. All values represent means ± SEM.