Fig. 4.

Diffusion tensor significance maps showing voxels with altered fractional anisotropy and mean diffusivity (a–f), or with altered axial- and radial diffusivity (a′–f′). The maps are presented in coronal slices (viewed from posterior) and show voxels with significantly different DTI metrics in HD rats, at a statistical significance level of p < 0.01, with a cluster threshold of 25 voxels. Significant DTI changes are seen in the ventral striatum (a, a′), dorsal striatum and globus pallidus (b, b′, c, c′), thalamus and medial globus pallidus (d, d′, e, e′), subthalamic region (e, e′), substantia nigra (f, f′) and the CA2 region of the hippocampus (f, f′). ac anterior commissure, Acb accumbens nucleus, CA2 field cornu ammonis 2 of the hippocampus, CPu caudate putamen complex, EP entopeduncular nucleus, gcc genu of the corpus callosum, GP globus pallidus, SN substantia nigra, STh subthalamic nucleus, tgHD transgenic HD rats, Thal thalamus, WT wild-type rats, ZI zona incerta. Scale bar 1 mm