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. 2012 Nov 28;23(4):390–401. doi: 10.1111/bpa.12005

Figure 1.

figure

Western blot analysis of human occipital lobe parenchyma (whole‐brain homogenate) in cases classified as control (n = 4), AD‐only (n = 4) and AD/CAA. AD/CAA cases were further categorized into ADmiCAA (n = 8), ADmodCAA (n = 4) and ADsevCAA (n = 4). A. Analysis of α2M, a major chaperone of the Aβ peptide, showed a significant decrease in mild, moderate and severe CAA compared to control and pure AD. B. Analysis of C3b, the ligand for CD11b and opsonin of the Aβ peptide, was significantly increased across the spectrum of CAA cases from mild, moderate and severe compared to controls, while moderate and severe CAA were both significantly increased from pure AD. *P < 0.05; **P < 0.01. Data represented as mean ± SEM. Relative abundance is the ratio of α2M and C3b: beta‐actin as optical density.