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. Author manuscript; available in PMC: 2014 May 1.
Published in final edited form as: Neurobiol Aging. 2012 Oct 27;34(5):1519.e5–1519.e12. doi: 10.1016/j.neurobiolaging.2012.10.003

Fig. 2. Histopathological findings in C9ORF72 expansion carriers.

Fig. 2

(A – C) The index case in family 6 showed classic AD changes including (A) neuronal loss and plaques (B) tau positive threads and tangles, and (C) amyloid plaques throughout the neocortex and hippocampus. (D – F) The index patient from family 2 showed (D) microvacuolation in the frontal cortex, (E) ubiquitin-immunoreactive intracellular inclusions in the hippocampus, and (F) cortical extracellular amyloid plaques. For more details see supplementary data.