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. Author manuscript; available in PMC: 2013 Mar 4.
Published in final edited form as: Cell Stem Cell. 2012 Mar 2;10(3):231–232. doi: 10.1016/j.stem.2012.02.008

Figure 1. Heregulin and IGF-1 via PI3K/Akt and Activin via Smad2/3 cooperate to maintain self-renewal of hESCs.

Figure 1

Red color indicates the activated state of signaling molecules whereas blue color indicates the repressive state. The dashed line indicates the regulation with unclear mechanisms.