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. 2013 Feb 19;2(2):e73. doi: 10.1038/mtna.2012.64

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Copyright © 2013 American Society of Gene & Cell Therapy

Molecular Therapy-Nucleic Acids is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution-NonCommercial- NoDerivative Works 3.0 License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/

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Experimental set-up and verification of BBB opening. (a) One hemisphere of male Wistar rats was insonated with a 500 kHz transducer adapted to a stereotactic positioning system. The transducer was driven by a function/arbitrary waveform generator and amplifier. (b) To demonstrate successful opening of the BBB, rats underwent magnetic resonance imaging 30 minutes after insonation. Gadolinium-enhanced T1-weighted images showed a slight contrast enhancement in the focus of the insonation site (see arrow).