Table 1.
Physiological parameters: blood pressure was monitored during the whole surgical procedure. pH, pCO2 and pO2, values were determined before occlusion (pre-ischemia) and 80 min after occlusion (post-ischemia).
| Thrombin | Thrombin + tPA 30 min | Thrombin + tPA 3 h | ||||
|---|---|---|---|---|---|---|
| Saline | FTY720 | Saline | FTY720 | Saline | FTY720 | |
| Blood pressure (mm Hg) | 84.3 ± 6.0 | 86.1 ± 7.3 | 86.0 ± 7.3 | 86.9±7.0 | 85.7 ± 7.7 | 82.7± 5.0 |
|
| ||||||
| pH (pre-ischemia) | 7.38 ± 0.07 | 7.39 ± 0.06 | 7.37 ± 0.08 | 7.38 ± 0.07 | 7.36 ± 0.06 | 7.35 ± 0.08 |
|
| ||||||
| pCO2 (pre-ischemia, mmHg) | 30.8 ± 4.8 | 31.0 ± 7.6 | 35.4 ± 7.7 | 34.5 ± 6.0 | 36.0 ± 7.2 | 37.2 ± 8.1 |
|
| ||||||
| pO2 (pre-ischemia, mmHg) | 142.7 ± 35.5 | 146.2 ± 23.3 | 160.3 ± 34.5 | 131.7 ± 31.5 | 133.9 ± 26.3 | 173.7 ± 25.9 |
|
| ||||||
| pH (post-ischemia) | 7.39 ± 0.08 | 7.33 ± 0.05 | 7.35 ± 0.09 | 7.32 ± 0.09 | 7.25 ± 0.12 | 7.25 ± 0.11 |
|
| ||||||
| pCO2 (post-ischemia, mmHg) | 43.7 ± 12.0 | 45.8 ± 12.2 | 51.1 ± 14.5 | 49.4 ± 11.6 | 48.4 ± 12.9 | 52.2 ± 15.5 |
|
| ||||||
| pO2 (post-ischemia, mmHg) | 132.2 ± 38.6 | 119.3 ± 38.4 | 142.4 ± 37.1 | 109.8 ± 34.4 | 115.7 ± 30.4 | 145.8 ± 14.6 |