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. Author manuscript; available in PMC: 2013 Mar 4.
Published in final edited form as: Anesthesiology. 2012 Feb;116(2):432–447. doi: 10.1097/ALN.0b013e3182423478

Table 5.

Methadone and metabolite renal excretion and clearance

Control Indinavir Control Indinavir
R-methadone
 S-methadone
% dose recovered 0-96 hr
 Intravenous d0-methadone 29 ± 10 33 ± 5 23 ± 9 26 ± 4
 Oral d5-methadone 24 ± 8 29 ± 3 * 20 ± 7 22 ± 3
 d0-EDDP 17 ± 5 15 ± 3 30 ± 10 31 ± 7
 d5-EDDP 18 ± 5 18 ± 2 30 ± 9 32 ± 6
Renal or metabolite formation
clearance (ml•kg−1•min−1)
 Intravenous d0-methadone Clr 0.48 ± 0.19 0.51 ± 0.18 0.30 ± 0.12 0.33 ± 0.11
 Oral d5-methadone Clr 0.40 ± 0.16 0.44 ± 0.14 0.25 ± 0.09 0.28 ± 0.08
 d0-EDDP Clf 0.27 ± 0.10 0.24 ± 0.08 * 0.39 ± 0.16 0.41 ± 0.17
 d5-EDDP Clf 0.29 ± 0.11 0.27 ± 0.09 0.38 ± 0.13 0.42 ± 0.17

Results are the mean ± SD (n=12) CLr, renal clearance; CLf, formation clearance; EDDP, 2-ethyl-1,5-dimethyl-3,3-diphenylpyrrolidine.

*

Significantly different from control (p<050.05)