Table 2.
Association of serum adiponectin levels with all-cause mortality, with estimated GFR used as a time-varying covariate
| Variable | Median ADPN Level (Range) | Hazard Ratio (95% Confidence Interval) | |||
|---|---|---|---|---|---|
| Unadjusted | Model 1a | Model 2b | Model 3c,d | ||
| Overall population | |||||
| Per natural log-transformed ADPN | 10.1 (0.04–127.1) | 1.76 (1.41–2.20) | 1.79 (1.43–2.26) | 1.62 (1.19–2.21) | 1.72 (1.22–2.44) |
| ADPN tertile | |||||
| 1 | 5.0 (0.04–7.4) | 1 (Reference) | 1 (Reference) | 1 (Reference) | 1 (Reference) |
| 2 | 10.1 (7.4–14.1) | 1.19 (0.72–1.95) | 1.13 (0.69–1.87) | 0.92 (0.46–1.85) | 1.11 (0.55–2.26) |
| 3 | 22.0 (14.1–127.1) | 2.17 (1.39–3.38) | 2.27 (1.43–3.60) | 1.77 (0.93–3.40) | 2.10 (1.05–4.22) |
ADPN (μg/ml), adiponectin.
a
Model 1 adjusts for age and sex.
b
Model 2 adjusts for covariates in model 1 plus time-varying estimated GFR, serum albumin, and log-transformed C-reactive protein.
c
Model 3 adjusts for covariates in model 2 plus Charlson Comorbidity Index score, abdominal circumference, systolic BP, time since kidney transplantation, and malnutrition-inflammation score.
d
Data available for n=952.