Table 1.
Demographic and presenting clinical data by FSGS histologic subtype
| Demographic and Presenting Clinical Data | Not Otherwise Specified | Tip | Collapsing | P Value |
|---|---|---|---|---|
| Total number of cases | 94 | 14 | 16 | — |
| Age at onset (yr) | 13 (8, 17) | 15 (10, 29) | 16.5 (14, 30.5) | 0.02 |
| Age group at onset (yr) | 0.03 | |||
| 2–12 (children) | 44 (47%) | 4 (29%) | 1 (6.3%) | |
| 13–17 (teenagers) | 27 (29%) | 4 (29%) | 9 (56%) | |
| ≥18 (adults) | 23 (24%) | 6 (43%) | 6 (38%) | |
| Age at biopsy (yr) | 14 (9, 18) | 15 (10, 30) | 16.5 (14.5, 31.5) | 0.05 |
| Male sex | 50 (53%) | 8 (57%) | 8 (50%) | 0.93 |
| Black race | 37 (39%) | 2 (14%) | 10 (63%) | 0.03 |
| Birth weight (kg; n*) | 3.4±0.7 (70) | 3.2±0.5 (13) | 2.7±0.8 (10) | 0.08 |
| Obesity at onset (n*) | 12 (20%) (59) | 2 (17%) (12) | 2 (18%) (11) | 0.91 |
| Hypertension | 55 (59%) | 8 (57%) | 7 (44%) | 0.54 |
| Edema | 34 (36%) | 8 (57%) | 11 (69%) | 0.03 |
| Nephrosis level | 0.03 | |||
| Mild | 29 (31%) | 1 (7%) | 1 (6%) | |
| Intermediate | 37 (39%) | 8 (57%) | 6 (38%) | |
| Severe | 28 (30%) | 5 (36%) | 9 (56%) | |
| Severe or intermediate nephrosis | 65 (69%) | 13 (93%) | 15 (94%) | 0.03 |
| Urine protein/creatinine ratio | 3.61 (1.77, 6.70) | 4.75 (3.49, 8.94) | 7.55 (4.35, 10.70) | 0.02 |
| Urine protein/creatinine ratio by level | 0.01 | |||
| 1–1.99 | 29 (31%) | 1 (7%) | 1 (6%) | |
| 2–3.99 | 23 (24%) | 4 (29%) | 3 (19%) | |
| 4–7.99 | 20 (21%) | 4 (29%) | 4 (25%) | |
| ≥8 | 22 (23%) | 5 (36%) | 8 (50%) | |
| Serum albumin (g/dl) | 2.98±0.93 | 2.54±0.95 | 2.49±0.74 | 0.04 |
| Cholesterol (mg/dl; n*) | 347±175 (86) | 429±109 (13) | 420±114 (15) | 0.002 |
| LDL (mg/dl; n*) | 197±132 (73) | 309±119 (11) | 253±102 (11) | <0.001 |
| Serum creatinine (mg/dl) | 0.86±0.61 | 0.84±0.43 | 1.33±0.50 | 0.003 |
| Baseline estimated GFR (ml/min per 1.73m2) | 121 (83, 206) | 120 (87, 180) | 82 (58, 108) | 0.006 |
Values are mean ± SD, median (25th, 75th percentile), or count (percent); n* is the available n for a given value. Where not specified, the available n is the same as the total number of cases in the top row. P values were calculated using Kruskal–Wallis tests for continuous variables, Pearson chi-squared tests for nominal categorical variables, and Cochran–Mantel–Haenszel tests for ordinal categorical variables.