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N-glycans but not O-glycans are required for the synthesis of SnL on activated CD4+ T cells. Splenocytes from WT mice were stimulated for 72 h in the presence of O-glycan elongation inhibitor (BenzylαGalNAc, top left panel), N-glycan inhibitor (DMNJ, top right panel), or relevant buffers. Cells were harvested and stained for Sn–Fc and biotinylated PNA (to confirm O-glycan inhibition in the presence of benzylαGalNAc) or biotinylated PHA (to confirm N-glycan inhibition).
