Table I.
Cancer genes | Targeted cell | Mechanism | Reference |
---|---|---|---|
Ependymoma models | |||
EphB2/Ink4a/Arf−/− | NSCs | Transplant | [57] |
Pilocytic astrocytoma models (I) | |||
BRAFV600E | Nestin | RCAS | [91] |
Astrocytoma models (II-III) | |||
v-src | GFAP | Transgenic | [97] |
Arf−/− | - | Transgenic | [98] |
c-myc | GFAP | Transgenic | [99] |
K-ras | GFAP | Cre | [100] |
H-Ras | GFAP | Transgenic | [101] |
H-Ras/Ptenloxp/loxp | GFAP | Cre | [102] |
T121/Pten+/− | GFAP | Cre | [103] |
EGFR/Ink4a/Arf−/− | Nestin | RCAS | [60] |
Oligodendroglioma models (II-III) | |||
H-ras | GFAP | Transgenic | [79] |
H-ras/EGFRvIII | GFAP | Transgenic | [62] |
v-ErbB/Ink4a/Arf+/− | S100β | Transgenic | [61] |
v-ErbB/Trp53−/− | S100β | Transgenic | [63] |
PDGFB/Ink4a/Arf−/− | - | Retroviral | [104] |
PDGFB/Ink4a/Arf−/− | Nestin | RCAS | [72] |
PDGFB/Akt | Nestin | RCAS | [105] |
PDGFB | CNP | RCAS | [73] |
PDGFB | Embryo | Retroviral | [69] |
PDGFAL | GFAP | Transgenic | [77] |
Glioblastoma (GBM) models (IV) | |||
Nf1+/−/Trp53+/− | - | Transgenic | [83] |
PDGFB | - | Retroviral | [70] |
PDGFB | Nestin | RCAS | [106] |
PDGFB/Trp53−/− | GFAP | Transgenic | [76] |
K-Ras/Akt | Nestin | RCAS | [80] |
K-Ras/Ink4a/Arf−/− | GFAP, Nestin | RCAS | [81] |
K-Ras/Akt/Ptenloxp/loxp | Nestin | RCAS/Cre | [107] |
Nf1loxp/+/Trp53+/− | GFAP | Cre | [85] |
Ptenloxp/+/Trp53loxp/loxp | GFAP | Cre | [108] |
Ptenloxp/+/Nf1loxp/+/Trp53loxp/− | GFAP | Cre | [87] |
p53−/− | Embryo | Mutagen | [109] |
Ptenloxp/+/Nf1loxp/+/Trp53loxp/loxp | SVZ, Nestin | CreER | [88] |
Akt/H-Ras/Trp53+/− | SVZ, HC, GFAP | Lentiviral/Cre | [82] |
Ptenloxp/loxp/Trp53loxp/loxp/Rbloxp/loxp | SVZ, GFAP | Adenoviral/Cre | [89] |
Nf1+/−/Trp53loxp/loxp | GFAP | Transgenic/Cre | [84] |
PDGFB/Ptenloxp/loxp/Trp53loxp/loxp | Subcortical WM | Retroviral/Cre | [78] |
Ptenloxp/loxp/Trp53loxp/loxp/Rb1loxp/loxp | Astrocyte (GFAP) OPC (NG2), NSCs (GFAP/Nestin) | CreER | [90] |
Nf1−/−/Trp53−/− | MADM/Cre | [94] | |
EGFRvIII/Ink4a/Arf−/− | NSC, Astrocyte | Transplant | [64] |
Pten−/−/EGFRvIII/ Ink4a/Arf−/− | Striatum | Adenoviral/Cre | [65] |
TGFα/EGFRwt/Ink4a/Arf−/− | Striatum | Lentiviral/Cre | [66] |
NSCs: neural stem cells; SVZ: Subventricular zone ;OPC: Oligodendrocyte precursor cell; WM: White matter. HC: Hippocampus.