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. Author manuscript; available in PMC: 2014 Apr 1.
Published in final edited form as: J Mol Med (Berl). 2012 Oct 23;91(4):497–506. doi: 10.1007/s00109-012-0965-1

Figure 1. Elevated Galectin-1 expression in human tumors versus normal tissues and anginex uptake in SCK tumors which is further augmented upon radiation exposure.

Figure 1

(A) Expression profile of Galectin-1 in normal human and corresponding tumor tissues of the lung, bladder and breast was analyzed by western immunoblotting (ProSci, CA) with Actin as the loading control. The band intensity was quantified by densitometry using Image J software. (B) Biodistribution of [18]-F-anginex and its radiation induced uptake in SCK murine mammary carcinoma grown in nu/nu mice. A markedly increased uptake of 18F]-anginex was observed in the SCK tumors as compared to the normal muscle tissue over the first 45 min post-i.p. injection. (C) Relative amount of radiation induced [18F]-anginex uptake in 5 individual SCK tumors in the rear limb of nu/nu mice one day before and 2 h after local irradiation of the tumor with 2 Gy. SUV: Standard Uptake Value. The uptake of Anginex in Animal 5 was 8 fold higher than baseline after radiation exposure.