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. Author manuscript; available in PMC: 2013 Mar 4.
Published in final edited form as: J Neuroparasitology. 2010 Oct;1:N100803.

Table 1.

Gene ontology terms of altered genes in CM brains.

A. GO terms upregulated in malarial brain
GOID GO name Ttype Number changed local Number measured local Number in GO local Percent changed local Z Score Permuted P
1584 rhodopsin-like receptor activity F 16 107 537 14.95327 3.388 0.001
3674 molecular_function F 1 22 673 4.545455 2.383 0.024
4888 transmembrane receptor activity F 1 15 88 6.666667 2.884 0.007
4930 G-protein coupled receptor activity F 3 25 469 12 3.546 0
4984 olfactory receptor activity F 28 193 1106 14.50777 2.61 0.013
5125 cytokine activity F 5 21 162 23.80952 2.449 0.018
6338 chromatin remodeling P 3 14 37 21.42857 2.326 0.042
7156 homophilic cell adhesion P 7 37 122 18.91892 2.058 0.038
7166 cell surface receptor-linked signal transduction P 3 13 140 23.07692 2.777 0.012
7186 G-protein coupled receptor protein signaling pathway P 49 355 1776 13.80282 2.291 0.024
7608 sensory perception of smell P 27 192 1095 14.0625 2.385 0.025
9968 negative regulation of signal transduction P 1 15 34 6.666667 2.378 0.019
16503 pheromone receptor activity F 6 25 150 24 2.572 0.022
42742 defense response to bacterium P 5 12 69 41.66667 3.442 0.006
50896 response to stimulus P 28 207 1194 13.52657 2.735 0.006
B. GO terms downregulated in malarial brain
16791 phosphoric monoester hydrolase activity F 1 18 12 5.555555 2.388 0.028
5925 focal adhesion C 3 14 30 21.42857 3.437 0.009
30141 secretory granule C 3 15 32 20 2.503 0.032
16323 basolateral plasma membrane C 2 18 32 11.11111 3.157 0.01
3746 translation elongation factor activity F 3 14 32 21.42857 3.437 0.016
16820 “hydrolase activity\, acting on acid anhydrides\, catalyzing transmembrane movement of substances” F 2 13 33 15.38461 0.805 0.455
6333 chromatin assembly or disassembly P 2 16 37 12.5 4.666 0
7179 transforming growth factor beta receptor signaling pathway P 1 10 41 10 1.525 0.185
151 ubiquitin ligase complex C 1 15 45 6.666667 1.441 0.155
6874 calcium ion homeostasis P 3 18 47 16.66667 2.892 0.03
43066 negative regulation of apoptosis P 3 23 57 13.04348 2.753 0.014
785 chromatin C 2 23 95 8.695652 2.797 0.015
3682 chromatin binding F 5 48 110 10.41667 2.286 0.041
786 nucleosome C 4 29 115 13.7931 2.805 0.019
42981 regulation of apoptosis P 1 33 116 3.030303 1.601 0.139
4721 phosphoprotein phosphatase activity F 3 12 120 25 2.601 0.025
7001 chromosome organization and biogenesis (sensu Eukaryota) P 4 29 124 13.7931 3.221 0.001
17111 nucleoside-triphosphatase activity F 1 31 125 3.225806 2.344 0.019
6334 nucleosome assembly P 6 36 125 16.66667 4.029 0.001
5694 chromosome C 4 58 166 6.896552 2.148 0.034
6629 lipid metabolic process P 5 66 217 7.575758 3.019 0.005
74 regulation of progression through cell cycle P 2 43 248 4.651163 2.346 0.028
6412 translation P 2 67 459 2.985075 2.199 0.036
5488 binding F 4 107 541 3.738318 3.217 0.003
3723 RNA binding F 10 138 544 7.246377 2.481 0.017
5739 mitochondrion C 18 276 813 6.521739 2.455 0.029
16787 hydrolase activity F 24 315 1273 7.619048 2.344 0.019
3676 nucleic acid binding F 11 245 1299 4.489796 2.664 0.008
5737 cytoplasm C 21 501 1495 4.191617 2.591 0.01
3677 DNA binding F 18 348 1725 5.172414 1.697 0.074
5622 intracellular C 22 567 1962 3.88007 2.935 0.008
46872 metal ion binding F 29 638 2173 4.545455 2.567 0.012
5634 nucleus C 67 1268 3680 5.283912 2.993 0.003
5515 protein binding F 84 1678 4425 5.00596 2.809 0.006

Number changed local = the number of genes altered in pathway; number measured local = number of genes in pathway with measurable signal; number in GO local = total number of genes in GO pathway.