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(a) MRI sagittal view of right knee of a rat. T1 weighted anatomical image depicting distal femoral diaphysis (L1), distal femoral epiphysis (L3), proximal tibial epiphysis (L4) and proximal tibial diaphysis (L5). (b) Dynamic contrast-enhanced MRI time–signal intensity curves. After bolus injection of Gd-DOTA, all four regions have a rapid rising phase. The time–signal intensity curves decrease after peak enhancement.
