Table 1.
Participant demographics, clinical and laboratory characteristics
| C | HCV | Co | HIV | P values | |
|---|---|---|---|---|---|
| N | 28 | 19 | 17 | 14 | |
| Age (yr) | 53.2 (6.0) | 56.6 (4.5) | 54.5 (5.2) | 51.6 (7.2) | 0.081 |
| Education (yr) | 15.4 (2.3) | 13.1 (2.2) | 13.4 2.1) | 13.6 (1.2) | 0.001 a |
| Ethnicity | 0.868 | ||||
| Asian | 2 | 0 | 0 | 0 | |
| African.American | 5 | 6 | 6 | 2 | |
| Caucasian | 19 | 11 | 10 | 11 | |
| Hispanic | 2 | 2 | 1 | 1 | |
| Estimated IQ (T score) | 57.2 (9.1) | 51.7 (8.6) | 49.0 (8.6) | 56.9 (8.1) | 0.010 b |
| Global deficit score | 0.30 (0.29) | 0.46 (0.34) | 0.77 (0.47) | 0.45 (0.36) | <0.001c |
| Beck Depression Inventory Score | 5.4 (4.1) | 6.7 (6.0) | 11.1 (7.5) | NA | 0.010 d |
| HCV RNA (log10 IU/mL) | NA | 5.9 (0.7) | 6.2 (0.5) | NA | 0.305 |
| HIV RNA (log10 RNA/mL) | NA | NA | UD | UD | NA |
| CD4 count (cells/ul) | NA | NA | 501 (243) | 516 (261) | 0.890 |
Note: Values are presented as mean (SD) except for N and ethnicity which were the number of individuals and drug abuse history which is percent. All participants were male. NA: not applicable or not available. C=controls, HCV=HCV monoinfection, Co=HIV/HCV coinfection, HIV=HIV monoinfection. UD=undetectable. P values stand for one-way ANOVA test except ethnicity (Chi-squared test). MANOVA was used in GDS and BDI with education and IQ as covariates. P values for HCV RNA and CD4 count were from Student’s t tests.
mean years of education of HCV, Co and HIV were lower than controls, no difference between them.
mean IQ of HCV and Co were lower than C, mean IQ of Co was lower than HIV.
mean GDS score of Co was higher than C after adjusting for education and IQ, Tukey HSD posthoc test p<0.001.
mean BDI of Co was higher than C and HCV after adjusting for education and IQ, Tukey HSD posthoc test p=0.010 and 0.049, respectively.