Table 1.
Papillary muscle fiber isometric tension. 1
| HCRLC variant | Extracted fraction (1-Tex/T0) |
Tension recovery (Trc/T0) |
n |
|---|---|---|---|
| WT | 0.53±0.09 | 0.85±0.03 | 5,4 2 |
| M20L | 0.51±0.1 | 0.86±0.05 | 3 |
| E134A | 0.54±0.04 | 0.75±0.01 | 4 |
| G162R | 0.53±0.02 | 0.91±0.03 | 4 |
| WT-PAGFP | 0.48±0.04 | 0.84±0.03 | 10 |
| M20L-PAGFP | 0.50±0.04 | 0.88±0.03 | 6 |
| E134A-PAGFP | 0.52±0.04 | 0.71±0.03 | 8 |
| G162R-PAGFP | 0.48±0.02 | 0.84±0.02 | 11 |
1
T0 is initial tension, Tex tension after extraction, and Trc tension measured after extraction and reconstitution of the HCRLC variants. Average T0 is 155±20 kN/m2 for the fibers tested. Tension recovery ≥ 80% indicates full recovery (see RESULTS: Fiber tension measurements). Errors are standard error of the mean for n experiments.
2
One fiber broke during reconstitution.