TABLE 2.
Common Adverse Events Experienced by > 10% of Rapid-Cycling Bipolar Disorder Patients During the Double-Blind Maintenance Phase
| Double-Blind Maintenance Phase | ||||
|---|---|---|---|---|
| Lithium (N = 16) | Lithium and Divalproex (N = 15) | |||
| Adverse Event | N | % | N | % |
| Tremors | 10 | 63 | 10 | 67 |
| Polyuria/Polydipsia | 5 | 31 | 6 | 40 |
| Diarrhea | 6 | 38 | 4 | 27 |
| Weight Gain | 5 | 31 | 2 | 13 |
| Fatigue | 1 | 6 | 5 | 33 |
| Nausea | 3 | 19 | 2 | 13 |
| Alopecia | 1 | 6 | 3 | 20 |
| Dry Mouth | 0 | 0 | 3 | 20 |
| Sexual Dysfunction | 2 | 13 | 2 | 13 |
| Cognitive Dysfunction | 2 | 13 | 2 | 13 |
| Blurred Vision | 1 | 6 | 2 | 13 |
| Increased Appetite | 2 | 13 | 0 | 0 |
| Acne | 2 | 13 | 0 | 0 |