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. Author manuscript; available in PMC: 2013 Mar 4.
Published in final edited form as: Alcohol Clin Exp Res. 2008 Mar 13;32(4):690–698. doi: 10.1111/j.1530-0277.2008.00625.x

Fig. 5.

Fig. 5

Acute ethanol has no effect on spontaneous GABAR-mediated IPSCs (sIPSCs) in mPFC pyramidal neurons. (A) Representative traces containing sIPSCs from PFC pyramidal neurons in the presence of NBQX (10 μM) and DL-APV (100 μM) before (left) and after (right) acute exposure to ethanol (88 mM). Scale bar: 25 pA, 5 ms. (B) Averaged sEPSCs before (black) and after (gray) acute exposure to ethanol (88 mM). (C,D) Average sIPSC amplitude (C) and frequency (D) normalized to baseline during (dark gray) and 15 to 20 minutes following (light gray) sham solution exchange (n=8) or exposure to 66 mM ethanol (n = 7), 88 mM ethanol (n = 8), or 50 μM pentobarbital (n=7). (E,F) sIPSC rise time (E) and decay time (F) before (white), during (dark gray), and 15 to 20 minutes following (light gray) sham solution exchange or exposure to 66 mM ethanol, 88 mM ethanol, or 50 μM pentobarbital. Values are expressed as averages ± SEM. *p < 0.001 compared with baseline values.