Skip to main content
. 2013 Jan 23;110(9):3477–3482. doi: 10.1073/pnas.1221924110

Fig. 4.

Fig. 4.

D(KLAKLAK)2 induces lipid bilayer disruption. (A) Fluorescence micrographs of giant unilamellar vesicles derived from E. coli extract containing Rh-PE after treatment with 3 µg of D(KLAKLAK)2 or control peptide. The punctuate appearance of lipids after treatment with D(KLAKLAK)2 indicates dissolution of giant unilamellar vesicles. (Scale bar: 100 µm.) (B) FRET between NBD-PE and Rh-PE as a result of D(KLAKLAK)2-induced liposome destruction (black line). No treatment (red line), control peptidomimetic (green line) and 95% ethanol treatment (blue line) served as negative and positive controls.