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. 2013 Jan 14;110(9):3549–3554. doi: 10.1073/pnas.1214912110

Table 2.

Calculated CMRglc(ox) derived from neuronal activity in rat somatosensory cortex for OGI of 5.6

Behavioral state* PR UR1 US1 AR AS UR2 US2 CR CS HR HS
Σ(δi fi ηN,i) (×103 spike.neuron.cm/s per centimeter3) 0.00 7,051 9,393 8,858 9,090 6,024 8,629 4,233 6,677 5,213 5,533
Σ(δi fi ηN,i)/Σδj (×107 spike.neuron/s per centimeter3) 0.00 3.71 4.95 4.67 4.79 13.36 19.13 9.39 14.80 11.56 12.27
Ens = Σ Pns,x × ηN,x (×1017 ATP/s per centimeter3) 0.76 0.76 0.76 0.76 0.76 0.76 0.76 0.76 0.76 0.76 0.76
Es = Ps × Σ(δi fi ηN,i)/Σδj (×1017 ATP/s per centimeter3) 0.00 1.79 2.38 2.24 2.30 1.53 2.19 1.07 1.69 1.32 1.40
Etot = Ens + Es (×1017 ATP/s per centimeter3) 0.76 2.55 3.14 3.01 3.07 2.29 2.95 1.84 2.45 2.08 2.16
calcCMRglc(ox) (μmol/g per minute) 0.22 0.72 0.89 0.85 0.87 0.65 0.83 0.52 0.69 0.59 0.61
measCMRglc(ox) (μmol/g per minute) 0.20 0.63 0.90 0.82 0.91 0.63 0.90 0.49 0.68 0.61 0.63

Details in Calculations. The calculated CMRglc(ox) [calcCMRglc(ox)] was determined from Eq. 3. The measured CMRglc(ox) [measCMRglc(ox)] was determined from Eq. 4 assuming OGI of 5.6. AR, awake rest; AS, awake stimulation; CR, α-chloralose rest; CS, α-chloralose stimulation; HR, halothane rest; HS, halothane stimulation; PR, pentobarbital; UR1, urethane rest; UR2, urethane rest; US1, urethane stimulation; US2, urethane stimulation.

*Details in SI Text, section 1 and see Fig. 1A for comparison between calcCMRglc(ox) and measCMRglc(ox).

Σδj was 1.90 mm (with Ps = 4.81 × 109 ATP/spike per neuron; see red circles in Fig. 1A).

Σδj was 0.45 mm [with Ps′ = (0.45/1.90) × Ps; see orange circles in Fig. 1A].