Table 2.
Calculated CMRglc(ox) derived from neuronal activity in rat somatosensory cortex for OGI of 5.6
Behavioral state* | PR | UR1† | US1† | AR† | AS† | UR2‡ | US2‡ | CR‡ | CS‡ | HR‡ | HS‡ |
Σ(δi fi ηN,i) (×103 spike.neuron.cm/s per centimeter3) | 0.00 | 7,051 | 9,393 | 8,858 | 9,090 | 6,024 | 8,629 | 4,233 | 6,677 | 5,213 | 5,533 |
Σ(δi fi ηN,i)/Σδj (×107 spike.neuron/s per centimeter3) | 0.00 | 3.71 | 4.95 | 4.67 | 4.79 | 13.36 | 19.13 | 9.39 | 14.80 | 11.56 | 12.27 |
Ens = Σ Pns,x × ηN,x (×1017 ATP/s per centimeter3) | 0.76 | 0.76 | 0.76 | 0.76 | 0.76 | 0.76 | 0.76 | 0.76 | 0.76 | 0.76 | 0.76 |
Es = Ps × Σ(δi fi ηN,i)/Σδj (×1017 ATP/s per centimeter3) | 0.00 | 1.79 | 2.38 | 2.24 | 2.30 | 1.53 | 2.19 | 1.07 | 1.69 | 1.32 | 1.40 |
Etot = Ens + Es (×1017 ATP/s per centimeter3) | 0.76 | 2.55 | 3.14 | 3.01 | 3.07 | 2.29 | 2.95 | 1.84 | 2.45 | 2.08 | 2.16 |
calcCMRglc(ox) (μmol/g per minute) | 0.22 | 0.72 | 0.89 | 0.85 | 0.87 | 0.65 | 0.83 | 0.52 | 0.69 | 0.59 | 0.61 |
measCMRglc(ox) (μmol/g per minute) | 0.20 | 0.63 | 0.90 | 0.82 | 0.91 | 0.63 | 0.90 | 0.49 | 0.68 | 0.61 | 0.63 |
Details in Calculations. The calculated CMRglc(ox) [calcCMRglc(ox)] was determined from Eq. 3. The measured CMRglc(ox) [measCMRglc(ox)] was determined from Eq. 4 assuming OGI of 5.6. AR, awake rest; AS, awake stimulation; CR, α-chloralose rest; CS, α-chloralose stimulation; HR, halothane rest; HS, halothane stimulation; PR, pentobarbital; UR1, urethane rest; UR2, urethane rest; US1, urethane stimulation; US2, urethane stimulation.
*Details in SI Text, section 1 and see Fig. 1A for comparison between calcCMRglc(ox) and measCMRglc(ox).
†Σδj was 1.90 mm (with Ps = 4.81 × 109 ATP/spike per neuron; see red circles in Fig. 1A).
‡Σδj was 0.45 mm [with Ps′ = (0.45/1.90) × Ps; see orange circles in Fig. 1A].