Table 2.
Genes up-regulated in response to metreleptin treatment at week 12 vs. baseline
| Gene symbol | Gene assignment | Gene ID | P value | Fold change |
| ADAM23 | ADAM metallopeptidase domain 23 | 8745 | 0.00657402 | 0.64445533 |
| Paep | Progestogen-associated endometrial protein | 5047 | 0.00268326 | 0.62717751 |
| SELE | Selectin E | 6401 | 0.0076583 | 0.56464262 |
| Zfp42 | Zinc finger protein 42 homolog (mouse) | 132625 | 0.00391605 | 0.54934091 |
| Vcam1 | Vascular cell adhesion molecule 1 | 7412 | 0.00908406 | 0.53175772 |
| ASB12 | Ankyrin repeat and SOCS box-containing 12 | 142689 | 0.00853215 | 0.52964533 |
| Tgm5 | Transglutaminase 5 | 9333 | 0.0037842 | 0.50489131 |
| MMP10 | Matrix metallopeptidase 10 (stromelysin 2) | 4319 | 0.00792751 | 0.49938345 |
| FSHB | Follicle stimulating hormone, beta polypeptide | 2488 | 0.00645861 | 0.46332061 |
| NTF3 | Neurotrophin 3 | 4908 | 0.00791533 | 0.45733451 |
| CYP1A1 | Cytochrome P450, family 1, subfamily A, polypeptide 1 | 1543 | 0.00851326 | 0.4530755 |
| actn3 | Actn3 | 89 | 0.00447152 | 0.42328933 |
| TUBGCP4 | Tubulin, gamma complex associated protein 4 | 27229 | 0.00366037 | 0.42254891 |
| LRRK1 | Leucine-rich repeat kinase 1 | 79705 | 0.00171516 | 0.38451621 |
| TREM2 | Triggering receptor expressed on myeloid cells 2 | 54209 | 0.00797656 | 0.37922294 |
| Il7 | Interleukin 7 | 3574 | 0.00912747 | 0.37264077 |
| EFEMP1 | EGF-containing fibulin-like extracellular matrix protein 1 | 2202 | 0.00731755 | 0.36643077 |
| ATP2C2 | ATPase, Ca++ transporting, type 2C, member 2 | 9914 | 0.00339537 | 0.36473719 |
| TM4SF4 | Transmembrane 4 L six family member 4 | 7104 | 0.00051904 | 0.36139 |
| Lama2 | Laminin, alpha 2 | 3908 | 0.00654983 | 0.35533335 |
| TRPM3 | Transient receptor potential cation channel, subfamily M, member 3 | 80036 | 0.00950655 | 0.33836606 |
| FUT3 | Fucosyltransferase 3 (galactoside 3 (4)-L-fucosyltransferase, Lewis blood group) | 2525 | 0.00877468 | 0.32655352 |
| Apobec1 | Apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1 | 339 | 0.00504257 | 0.32323031 |
| tcf7l1 | Transcription factor 7-like 1 (T-cell specific, HMG-box) | 83439 | 0.00841957 | 0.31810237 |
| FOXD3 | Forkhead box D3 | 27022 | 0.00455988 | 0.31602 |
| Gpr20 | G protein-coupled receptor 20 | 2843 | 0.00566617 | 0.30375888 |
| Hdac10 | Histone deacetylase 10 | 83933 | 0.00432499 | 0.28392 |
| Krt32 | Keratin 32 | 3882 | 0.00276204 | 0.26272288 |
| CD1E | CD1e molecule | 913 | 0.00678964 | 0.24852336 |