Table 1.
ERAD component | % cells* | Average RZ score | Average RZ score rank‡ |
Hrd1 | 18.69 | −3.84 | 1 |
HERP | 63.01 | −2.58 | 41 |
SEL1L | 63.62 | −2.50 | 61 |
UFD1 | 87.46 | −2.41 | 91 |
PNGase | 60.45 | −2.36 | 117 |
p97 | 33.68 | −2.31 | 143 |
Sec61-γ | 51.48 | −2.21 | 215 |
FAF2/UbxD8 | 113.39 | −2.08 | 336 |
NPL4 | 56.73 | −2.04 | 409 |
AUP1 | 60.13 | −1.74 | 1,012 |
Sec61-α1 | 19.96 | −1.64 | 1,320 |
Golgi mannosidase I | 39.55 | −1.53 | 1,686 |
EDEM2 | 54.67 | −1.33 | 2,402 |
Derlin-2 | 26.50 | −1.12 | 3,341 |
HR23B | 30.47 | −1.07 | 3,582 |
Erdj3 | 22.60 | −1.07 | 3,612 |
EDEM3 | 55.67 | −0.88 | 4,507 |
Erdj5 | 22.21 | −0.86 | 4,626 |
ER mannosidase I | 15.60 | −0.84 | 4,741 |
XTP3-B | 35.54 | −0.78 | 5,004 |
OS-9 | 96.48 | −0.51 | 6,388 |
Derlin-1 | 47.20 | −0.35 | 7,168 |
VIMP | 68.70 | 2.48 | 1,627 |
Hsp90 | 83.70 | 1.86 | 2,575 |
Derlin-3 | 46.83 | 1.71 | 2,899 |
EDEM1 | 63.33 | 1.70 | 2,909 |
Gp78 | 78.26 | 1.23 | 4,156 |
Sec61α2 | 32.26 | 0.91 | 5,237 |
Bip/Grp78 | 52.20 | 0.75 | 5,868 |
Grp94 | 34.03 | 0.58 | 6,561 |
Sec61-β | 41.19 | 0.53 | 6,773 |
*Percentage of cells analyzed in knockdown wells versus the negative control siRNA wells.
‡A ranked list was sorted on inhibitors or enhancers.