Table 1.
Genomewide screen results for known or potential ERAD factors
| ERAD component | % cells* | Average RZ score | Average RZ score rank‡ |
| Hrd1 | 18.69 | −3.84 | 1 |
| HERP | 63.01 | −2.58 | 41 |
| SEL1L | 63.62 | −2.50 | 61 |
| UFD1 | 87.46 | −2.41 | 91 |
| PNGase | 60.45 | −2.36 | 117 |
| p97 | 33.68 | −2.31 | 143 |
| Sec61-γ | 51.48 | −2.21 | 215 |
| FAF2/UbxD8 | 113.39 | −2.08 | 336 |
| NPL4 | 56.73 | −2.04 | 409 |
| AUP1 | 60.13 | −1.74 | 1,012 |
| Sec61-α1 | 19.96 | −1.64 | 1,320 |
| Golgi mannosidase I | 39.55 | −1.53 | 1,686 |
| EDEM2 | 54.67 | −1.33 | 2,402 |
| Derlin-2 | 26.50 | −1.12 | 3,341 |
| HR23B | 30.47 | −1.07 | 3,582 |
| Erdj3 | 22.60 | −1.07 | 3,612 |
| EDEM3 | 55.67 | −0.88 | 4,507 |
| Erdj5 | 22.21 | −0.86 | 4,626 |
| ER mannosidase I | 15.60 | −0.84 | 4,741 |
| XTP3-B | 35.54 | −0.78 | 5,004 |
| OS-9 | 96.48 | −0.51 | 6,388 |
| Derlin-1 | 47.20 | −0.35 | 7,168 |
| VIMP | 68.70 | 2.48 | 1,627 |
| Hsp90 | 83.70 | 1.86 | 2,575 |
| Derlin-3 | 46.83 | 1.71 | 2,899 |
| EDEM1 | 63.33 | 1.70 | 2,909 |
| Gp78 | 78.26 | 1.23 | 4,156 |
| Sec61α2 | 32.26 | 0.91 | 5,237 |
| Bip/Grp78 | 52.20 | 0.75 | 5,868 |
| Grp94 | 34.03 | 0.58 | 6,561 |
| Sec61-β | 41.19 | 0.53 | 6,773 |
*Percentage of cells analyzed in knockdown wells versus the negative control siRNA wells.
‡A ranked list was sorted on inhibitors or enhancers.