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. Author manuscript; available in PMC: 2013 Dec 1.
Published in final edited form as: Curr Opin Cell Biol. 2012 Sep 17;24(6):775–783. doi: 10.1016/j.ceb.2012.08.008

Figure 2.

Figure 2

(A) NUP155 regulates the export of Hsp70 mRNA and import of Hsp70 protein in cardiac muscle, a function NUP155 loses in atrial fibrillation. In cardiomyocytes, NUP155 mediates localization and activity of HDAC4. Addition of NUP210 to NPCs induces activation of genes critical for myogenesis and the differentiation of ES cells into NP cells. In Drosophila, several dynamic NPC components shuttle off the pore to regulate the expression of developmental genes inside the nucleoplasm. (B) Lack of a replacement mechanism of NPCs in post-mitotic cells results in deterioration of NPCs over time and progressive loss of cell compartmentalization.