Table 1.
Patient characteristics
| All Patients (N=311) | Typical AF (N=278) | Lone AF (N=33) | |
|---|---|---|---|
| Age | 60(52,66) | 61(55,67) | 49(44,52) |
| Male | 72%(224) | 71%(198) | 79%(26) |
| Body Mass Index (kg/m2) | 30(27,35) | 30(27,35) | 27(26,34) |
| Paroxysmal AF | 47%(147) | 44%(123) | 73%(24) |
| Time since AF diagnosis (months) | 57(26,105) | 59(28,106) | 37(18,87) |
| Number of Prior Direct Current Cardioversions | 2(2,9) | 3(2,9) | 2(2,3) |
| Number of Failed Antiarrhythmic Drugs | |||
| 0 | 6%(19) | 5%(14) | 15%(5) |
| 1 | 44%(138) | 45%(125) | 39%(13) |
| 2 | 30%(93) | 29%(82) | 32%(11) |
| 3 | 14%(44) | 15%(43) | 3%(1) |
| 4 | 5%(14) | 4%(11) | 9%(3) |
| 5 | 1%(2) | 1%(2) | 0%(0) |
| 6 | 0%(1) | 0%(1) | 0%(0) |
| Previously Failed Amiodarone | 35%(110) | 37%(104) | 18%(6) |
| Coronary Artery Disease | 17%(54) | 19%(54) | 0%(0) |
| Congestive Heart Failure | 10%(30) | 11%(30) | 0%(0) |
| Left Atrial Size (mm) | 38(33,44) | 39(34,45) | 35(29,39) |
| Left Ventricular Ejection Fraction from MRI (%) | 65(56,71) | 65(56,71) | 64(59,68) |
| Genotypes | |||
| rs2200733 (4q25) | |||
| CC | 59%(184) | 62%(171) | 39%(13) |
| CT | 34%(105) | 32%(89) | 48%(16) |
| TT | 7%(21) | 6%(17) | 12%(4) |
| Failed Genotyping | 0%(1) | N/A | N/A |
| Minor Allele Frequency | 25% | 22% | 36% |
| rs10033464 (4q25) | |||
| GG | 76%(237) | 76%(212) | 76%(25) |
| GT | 22%(69) | 22%(62) | 21%(7) |
| TT | 2%(5) | 1%(4) | 3%(1) |
| Failed Genotyping | 0%(0) | N/A | N/A |
| Minor Allele Frequency | 13% | 14% | 14% |
Continuous variables are median and interquartile range. Categorical variable are percentage and frequency. For rs2200733 cytosine (C) is the wildtype and T (thymine) is the risk allele. For rs10033464 guanine (G) is the wildtype and T is the risk allele.