Figure 3.

Mediational analysis model, illustrating that the change in SF-36 domain score (overall treatment effect) may be due to a direct effect of pregabalin on that particular SF-36 domain (direct effect) or may be mediated through pregabalin-driven pain relief or improvements in sleep (indirect effects).

Note: Reprinted from The Journal of Pain. Vinik A, Zlateva G, Cheung R, Murphy K, Emir B, Whalen E. Understanding the impact of pain response on changes in function, quality of life, and sleep interference in patients with painful diabetic peripheral neuropathy and post-herpetic neuralgia treated with pregabalin. 2010;11:S17. Copyright 2010 with permission from Elsevier.²⁰